Cats & Dogs: The Revenge of Kitty Galore

At a satellite base in Northern Germany, a worker named Freidrich (Fred Armisen), delivering secret codes finds a Cocker Spaniel puppy outside his office. He brings the puppy inside, showing her to his Bloodhound, Rex. Rex senses something is wrong with the puppy and starts to bark at her, making the worker take him outside. Both are locked out of the office. Rex looks in the window seeing the puppy taking pictures of the top secret documents and later revealing to be Kitty Galore (voiced by Bette Midler), an evil female hairless cat. Rex turns out to be a dog agent and reports to HQ. In San Francisco, Diggs (voiced by James Marsden), a German Shepherd police dog and his master, Shane (Chris O'Donnell) are called to a hostage situation at Crazy Carlito's used car lot. Diggs deliberately ignores Shane's commands, attacking Crazy Carlito (Paul Rodriguez) and causing him to release a device that Diggs grabs which causes the car lot office to blow up. Butch, an Anatolian Shepherd, (voiced by Nick Nolte) and Lou, now the Beagle chief incharge of Dog HQ, (voiced by Neil Patrick Harris) are watching a footage of the incident. Lou, no longer a field agent having been promoted to official level hence being termed "desk jockey" by Butch, wants Diggs to be an agent with Butch as his mentor (to his reluctance) to help bring down Kitty Galore. At the police station, Diggs is suspended and sent back into the kennels. Shane wants to adopt Diggs but the police will not allow it. Shane promises Diggs that he will get him out and he also tells Diggs that that life is not about being top dog and he must learn to work with other people and listen to other people. Butch comes out of the floor of the kennel and recruits Diggs and takes him to D.O.G. HQ in a rocket. Lou shows them a video they received three hours ago. The video happens to be from Kitty Galore. In the video, she explains that she is going to broadcast a sound (she calls it the "Call of the Wild") that will drive all dogs completely insane all around the world, and without the dogs to protect the humans, she will enslave all mankind. Lou explains that Kitty has been trying to track down a stool pigeon named Seamus (voiced by Katt Williams), and that if they find Seamus, he can lead them to Kitty. Lou sends them on a mission to find Seamus and stop Kitty from broadcasting her "Call of the Wild"...