The West Wing, like many serial dramas, stretches storylines over several episodes or entire seasons. In addition to these larger storylines, each episode also contains smaller arcs which usually begin and end within an episode.

Most episodes follow President Bartlet and his staff through particular legislative or political issues. Plots can range from behind-closed-doors negotiating with Congress ("Five Votes Down") to personal issues like sex ("Pilot", "Take out the Trash Day") and personal drug use (a major plotline throughout the first and second seasons). The typical episode loosely follows the president and his staff through their day, generally following several plots connected by some idea or theme. A large, fully connected set of the White House allows the producers to create shots with very few cuts and long, continuous master shots of staff members walking and talking through the hallways. These "walk and talks" became a trademark of the show. The final two seasons presented a narrative change, with the focus of the show divided between plots in the West Wing with President Bartlet and his remaining senior staffers and plots revolving around the rest of the main cast on the campaign trail for the The West Wing presidential election, 2006|2006 election.